Recent Oral Presentations

“Understanding accumulation and persistence of polymyxins in the kidney is crucial for design of improved analogues” presented at ECCMID, Madrid, April 2018
“Novel Polymyxin derivatives for Gram-negative infections” presented at BristolBridge Annual Conference, University of Bristol, 11th May 2017
“Next generation antibacterials inspired by natural products” presented at SCI Young Chemists’ symposium: New Approaches in Medicinal Chemistry ll, Eli Lilly, Windlesham 1st February 2017
“Novel Polymyxin derivatives for Gram-negative infections: Synthesis and SAR” presented at RSC/SCI: Plugging the Antibiotics Gap: A Medicinal Chemist’s Perspective, Alderley Park, 16th November 2016

Publications

P. Brown, E. Abbott, O. Abdulle, S. Boakes, S. Coleman, N. Divall, E. Duperchy, et al., ACS Infect. Dis. (2019), 5, 1645–1656. Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206 doi:10.1021/acsinfecdis.9b00217
P. Brown and M.J. Dawson, The Journal of Antibiotics (2017), 70, 386–394. Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections doi:10.1038/ja.2016.146
T.J. Miles, A.J. Hennessy, B. Bax, G. Brooks, B.S. Brown, P. Brown, et al. Bioorganic & Medicinal Chemistry Letters (2016), 26(10), 2464–2469. Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases doi:10.1016/j.bmcl.2016.03.106
P. Brown, M.J. Dawson. A perspective on the next generation of antibacterial agents derived by manipulation of natural products in Progress in Medicinal Chemistry, 54, G. Lawton, and D.R. Witty, Eds, Elsevier, (2015), 135–184. doi:10.1016/bs.pmch.2014.10.001
T.J. Miles, A.J. Hennessy, B. Bax, G. Brooks, B.S. Brown, P. Brown, et al. Bioorganic & Medicinal Chemistry Letters (2013), 23(19), 5437–5441. Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases doi:10.1016/j.bmcl.2013.07.013
T.J. Miles, J.M. Axten, C. Barfoot, G. Brooks, P. Brown, et al Bioorganic & Medicinal Chemistry Letters (2011), 21(24), 7489–7495. Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases doi:10.1016/j.bmcl.2011.09.117
T.J. Miles, C. Barfoot; G. Brooks, P. Brown, et al. Bioorganic & Medicinal Chemistry Letters (2011), 21(24), 7483–7488. Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases doi:10.1016/j.bmcl.2011.09.114
C.W. Barfoot, P. Brown, S. Dabbs, D.T. Davies, A.J. Hennessy, T.J. Miles, N.D. Pearson Tetrahedron Letters 2010, 51(38), 5038–5040. The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde doi:10.1016/j.tetlet.2010.07.099
C. Barfoot, G. Brooks, P. Brown, S. Dabbs, D.T. Davies, et al. Tetrahedron Letters 2010, 51(20), 2685–2689. Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides doi:10.1016/j.tetlet.2010.03.051
R.L. Jarvest, S.A. Armstrong, J.M. Berge, P. Brown, et al. Bioorg. Med. Chem. Lett. 2004, 14, 3937–3941. Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: Potent antibacterially active non-quinolone analogues
R.L. Jarvest, J.M. Berge, P. Brown, et al. Bioorg. Med. Chem. Lett. 2003, 13 1265–1268. Conformational restriction of Methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent Gram-positive Antibacterial Activity
R.L. Jarvest, J.M. Berge, M.J. Brown, P. Brown, et al. Bioorg. Med. Chem. Lett. 2003, 13, 665. Optimisation of Aryl Substitution Leading to Potent Methionyl tRNA Synthetase Inhibitors with excellent Gram-Positive Antibacterial Activity
X. Qiu, C. Janson, W.W. Smith, S.M. Green, P. McDevitt, K. Johanson, P. Carter, M. Hibbs, C. Lewis, N. Campobasso, J. Lalonde, J. Berge, P. Brown, et al. Protein Science 2001, 10 (10), 2008–2016. Crystal Structure of Staphylococcus aureus Tyrosyl-tRNA Synthetase
R.L.Jarvest, J.M. Berge, P. Brown, D.W. Hamprecht, D.J. McNair, L. Mensah, P.J. O'Hanlon and A.J. Pope Bioorg. Med. Chem. Lett. 2001, 11, 715. Potent Synthetic Inhibitors of Tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383
P. Brown, D.R. Eggleston, R.C. Haltiwanger, R.L. Jarvest, L. Mensah, P.J. O'Hanlon and A.J. Pope Bioorg.Med.Chem Lett 2001, 11, 711. Synthetic analogues of SB-2129383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase
P. Brown, C.M. Richardson, et al . Bioorg. Med. Chem. 1999, 7, 2473. Molecular recognition of Tyrosinyl Adenylate analogues by Prokaryotic Tyrosyl tRNA synthetase
P. Brown, D.J. Best, N.J.P. Broom, R. Cassels, et al J.Med. Chem. 1997, 40, 2563. The Chemistry of Pseudomonic Acid 18. Heterocyclic Replacement of the alpha-beta unsaturated ester : Synthesis, molecular Modelling and Antibacterial Activity
P. Brown, D.T. Davies, P.J. O'Hanlon and J.M Wilson J.Med. Chem. 1996, 39, 446. The Chemistry of Pseudomonic Acid, Part 15
P. Brown and P.J. O'Hanlon Tetrahedron Letters 1994, 35, 9619. Novel Synthesis of a mixed Phosphonic Anhydride
G. Walker, P. Brown, P.J. O'Hanlon et. al New Antibacterial Agents in Recent Advances in the Chemistry of Anti-infective Agents RSC, 1993, p106.
P. Brown, S.H. Calvert, P.A. Chapman, S.C. Cosham, A.J. Eglington, R.L. Elliot, M.A. Harris, et al J. Chem. Soc. Perkin Trans. 1 1991, 881. beta-Lactamase stable Penicillins
P. Brown (neé Davis) and R. Southgate Tetrahedron Letters 1986, 27, 247. A stereocontrolled route to optically active 1-methyl Carbapenems
M.J. Basker, R.J. Boon, S.J. Box, P. Davis, R.J. Ponsford, R. Southgate, and S.R. Spear. The Journal of Antibiotics 1983,36, 1357. Comparative Antibacterial Properties of some Synthetic Olivanic Acid Analogues
A.J.G. Baxter, P. Davis, R.J. Ponsford, and R. Southgate Tetrahedron Letters 1980, 21, 5071. Synthesis of Olivanic acid analogues

Patents

WO 2016083531 P. Brown, M. Dawson, M. Simonovic et al. Preparation of polymyxin derivatives for treating bacterial infections
WO 2015135976 P. Brown, M. Dawson, M. Simonovic et al. Polymyxin Derivatives and their use in combination therapy for treating microbial infections
WO 2014188178 P. Brown, M. Dawson, M. Simonovic, S. Boakes, E. Duperchy Preparation of polymyxin derivatives and their use in combination therapy together with different antibiotics
WO 2013072695 M. Saadi, E. Duperchy, P. Brown, M.J. Dawson, S.N. Wadman Polymyxin derivatives for treatment of microbial infections
WO2009/087153 P. Brown, S. Dabbs, A. Hennessy Tricyclic nitrogen compounds as antibacterial agents and their preparation
WO2008/128953 P. Brown, S. Dabbs Tricyclic compounds as antibacterial agents and their preparation, pharmaceutical compositions and use in the treatment of bacterial infections
WO2008/116815 P. Brown, S. Dabbs, D.T. Davies, N.D. Pearson Heterotricyclic compounds as antibacterial agents and their preparation, pharmaceutical compositions and use in the treatment of bacterial infections
WO2004/058144 J. Axten, G. Brooks, P. Brown et al. Quinoline and Naphthyridine derivatives as antibacterial agents
WO2004/689886 P. Brown, E. Hunt Pleuromutilin derivatives as antibacterial agents
WO2000/71524 S.A. Armstrong, J.M. Berge, P. Brown, J.S. Elder, A.K. Forrest, D.W. Hamprecht, R.L. Jarvest Methionyl tRNA synthetase inhibitors
WO99/55677 J.M. Berge, P. Brown, J.S. Elder, A.K. Forrest, D.W. Hamprecht, R.L. Jarvest, D.J. McNair, R.J. Sheppard Methionyl tRNA synthetase inhibitors
WO 95/16686 P.J. O'Hanlon, P. Brown Mupirocin derivatives
WO 94/28001 K. Baggaley, N. Broom, P. Brown, P. O'Hanlon, N. Osborne 4-Hydroxy monic acid-pyrrothine esters
EP 93485-A 9/11/83 R. Southgate, P. Brown Optically active carbapenem intermediates
EP 89139-A R. Southgate, P. Brown 2-Pyrimidinylthio carbapenems as antibacterial agents
EP 60612-A D.F. Corbett, P. Brown, R.J. Ponsford Sulphoxide displacement in carbapenems